It's hard to determine what constitutes a normal toxic or lethal dose. Nonetheless, the lethal oral dose of codeine in an Grownup is documented to get inside the variety of 0.

In the event you miss out on a dose, just take it when you are able to. If it is nearly time in your future dose, choose only that dose. Will not take double or excess doses.

Explain to your doctor In case you are Expecting or Consider you could be pregnant. For the duration of pregnancy, this product or service is not really proposed. It could harm an unborn toddler. Speak with your medical doctor about the dangers and benefits of this medication. See also Warning area.

Indicators and indicators of overdosage with promethazine HCl vary from gentle melancholy of the central nervous procedure and cardiovascular procedure to profound hypotension, respiratory depression, unconsciousness, and unexpected Dying.

Considering the fact that recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine HCl really should be meticulously regarded as.

Effects around the Immune Process Opioids happen to be revealed to possess several different effects on components of the immune process in in vitro and animal products. The medical importance of these results is unfamiliar. Over-all, the consequences of opioids seem like modestly immunosuppressive.

Usually do not consider this medication for several days just before allergy tests because check Promethazine codeine syrup results might be affected.

Codeine Within an embryofetal advancement study in Expecting rats dosed all through the period of organogenesis, codeine improved resorptions and lowered fetal weights at a dose roughly twenty five times the MRHD (on a mg/m2 foundation with a maternal oral dose of a hundred and twenty mg/kg/day); however, these consequences transpired in the presence of maternal toxicity.

The lowest successful dosage ought to be utilised, along with other medication that have an affect on respiratory should be averted. Get medical aid at once in the unlikely occasion that gradual/shallow respiratory takes place. Promethazine shouldn't be utilized by little ones with liver disorder (including attainable Reyes syndrome).

The next laboratory assessments can be affected in sufferers that are receiving therapy with promethazine hydrochloride.

Take this medication by mouth with or with out foods as directed by your physician, generally each four to 6 hours as wanted. This medication is often taken with meals if abdomen upset takes place. Consume lots of fluids whenever you use this medication Until if not directed by your health care provider.

Codeine Codeine and its Energetic metabolite, morphine, are current in human milk. You will find published reports and situations that have noted too much sedation, respiratory depression and Loss of life (in one toddler) in infants exposed to codeine by using breast milk. Gals who are ultra-rapid metabolizers of codeine achieve higher than predicted serum amounts of morphine, possibly bringing about increased amounts of morphine in breast milk which might be harmful inside their breastfed infants.

When useful for an prolonged time, this medication may not get the job done likewise and should demand various dosing. Talk with your medical doctor if this medication stops working well.

INDICATIONS AND Use Promethazine HCl and Codeine Phosphate Oral Option is a mix of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the short-term aid of cough and upper respiratory signs related to allergy or even the prevalent cold in people 18 a long time of age and older. (1)